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The Alteration of Bacterial Endotoxins by Human and Rabbit Serum¹

From the Department of Bacteriology, The University of Michigan, Ann Arbor, Michigan

Abstract

Incubation of Salmonella typhosa endotoxin in normal human and rabbit serum was found to alter the precipitating activity of the endotoxin. By quantitative techniques, it was demonstrated that the extent of alteration is a function of time and temperature of incubation, pH and concentration of serum and endotoxin. The serum factor appeared to be relatively stable at 56°C. Evidence was presented that eliminated the properdin system as responsible for the alteration. The characteristics of this reaction are discussed.

Footnotes

This investigation was supported in part by research grant E 1524 from the National Institute of Allergy and Infectious Diseases, U. S. Public Health Service. Presented in part before the American Association of Immunologists' meeting, April 1957, Chicago, Illinois (1).

² Captain, U.S.A.F. Present address: USAF Epidemiologic Laboratory, Lackland A.F.B., Texas. Taken in part from a dissertation submitted to the Graduate School, The University of Michigan, Ann Arbor, Michigan in partial fulfillment of requirements for the degree of Doctor of Philosophy.