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Study on the Growth of Rickettsiae

IV. Effect of Chloramphenicol and several Metabolic Inhibitors on the Multiplication of Rickettsia Tsutsugamusi in Tissue Culture Cells

From the Laboratory of Infectious Diseases, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland

Abstract

Under certain conditions chloramphenicol can exert a rickettsicidal effect. L929 cell cultures heavily infected with Rickettsia tsutsugamushi were completely freed of their organisms after 3–4 weeks' treatment with 5 µg/ml of chloramphenicol; the rate of rickettsial inactivation by this concentration of antibiotic appears to be a function of temperature.

Sodium azide (1 x 10^-4 M) exerted a more deleterious effect on intracellular rickettsial multiplication than either cyanide or dinitrophenol although all three substances had a similar inhibitory effect on the growth of L cells. Suppression of rickettsial growth by -2-thienylalanine, ethionine and methionine sulfoxide occurred at concentrations which were not obviously toxic to the host cell.

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