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Immunity Afforded by Specifically Absorbed, Unabsorbed and Combinations of Salmonella Antisera

From the Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Laboratory of Clinical Investigation, Bethesda, Maryland

Abstract

Employing Salmonella typhimurium and Salmonella enteriditis, and their respective immune sera, absorbed, and native, in mouse protection tests, the relationship of antibody components in conferring protection was investigated by altering an immune serum so that only one reactive component remained, and by quantitatively increasing a component in both unheated and inactivated immune sera.

An absorbed serum containing only antibody to somatic antigen 9 gave greater protection than the native immune serum. Enhancement of protection occurred when a single antibody component, 12₁,12₂ was increased in amount in mixtures of the two immune sera. This increase of protection was independent of complement. The degree of enhancement and the degree of protection was not the same in all experiments and depended upon more than the interactions of the 12₁,12₂ components present.

Mechanisms which might possibly explain these results are discussed.