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Studies on the Complement Fixing Antigens of Poliomyelitis¹

I. Demonstration of Type and Group Specific Antigens in Native and Heated Viral Preparations

From the Division of Virology, The Department of Public Health and Preventive Medicine, School of Medicine, University of Pennsylvania and The Children's Hospital of Philadelphia, Pennsylvania

Abstract

The antibody responses of animals and man following infection and immunization with poliomyelitis viruses were investigated by absorption techniques.

1. Sera from animals, immunized with a single type of virus, contained two distinct complement fixing antibodies, both of which were found to be type specific.

2. The presence of antigenic components common to two or all three types of virus was demonstrated by absorption of a chimpanzee and a human serum with heated antigen preparations.

3. Absorption of a human serum with native type II antigen gave direct evidence that this type of virus in its native state contains antigenic components present in the two heterologous types of virus whereas types I and III absorbed only their homologous antibodies.

Footnotes

This work was supported by a grant-in-aid from the National Institutes of Health, USPHS.

² Present address: Charles Pfizer and Company, Inc., Terre Haute, Indiana.

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				O. Goetz and K. Hummeler Diagnosis of Poliomyelitis: Problems in the Laboratory Clinical Pediatrics, November 1, 1963; 2(11): 601 - 604. [PDF]