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Cytopathogenicity and Propagation of Variola Virus in Tissue Culture¹

From the U. S. Army Chemical Corps, Fort Detrick, Frederick, Maryland

Abstract

Variola virus has been shown to induce cytologic changes and to propagate in a variety of human and animal cell strains derived from both normal and malignant tissue. One exception occurred in which the L cell strain was agglutinated by large virus quantities. The cytologic changes and agglutination were prevented by specific immune serum. A linear logarithmic relationship existed between the quantity of virus used and the quantity of serum required to neutralize the virus in a tissue culture neutralization test.

Footnotes

¹ This paper was presented in part before the Tissue Culture Association, Ninth Annual Meeting, April 10, 1958.