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Passive Cutaneous Anaphylaxis in the Mouse¹

From the Department of Microbiology, The Johns Hopkins University School of Hygiene and Public Health, Baltimore, Maryland

Abstract

The skin of the albino Swiss mouse can be passively sensitized by rabbit antibody. With the rabbit antihen egg albumin used in this study, 0.4 or 0.8 µg antibody nitrogen was found to be the lower limit necessary for local sensitization. The optimal latent period was found to be 3 hr. Intradermally injected antibody can be detected by PCA for only a short time after challenge with antigen. When the antibody is injected intravenously, 350 µg of antibody nitrogen or more are necessary to sensitize the skin. At these antibody levels the threshold amount of Ea approximated 0.25 µg.

Footnotes

¹ This work was performed during a Fulbright Fellowship (1954–1955). It was also supported in part by a grant from the National Science Foundation and by a Contract (Nonr 248(17) with the Office of Naval Research.

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				A. J. CROWLE Delayed Hypersensitivity in Mice: Its Detection by Skin Tests and Its Passive Transfer Science, July 17, 1959; 130(3368): 159 - 160. [Abstract] [PDF]