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The Specific Hapten of Group C (Group II ) Meningococcus

I. Preparation and Immunological Behavior¹

From the Department of Bacteriology, University of Rochester School of Medicine and Dentistry, Rochester, New York

Abstract

Soluble specific substances were prepared from 3 representative strains of Group C (formerly Group II ) meningococci. Dilutions as high as 1:4,000,000 of all preparations gave positive precipitin reactions with homologous rabbit antiserum. However, all evidenced some degradation of immunologic integrity, e.g., the best preparation absorbed only of the homologous mouse-protective activity from a rabbit Group C antiserum and it failed to engender significant active immunity in mice. On the other hand, intraabdominal injection of 30 µg of this preparation/animal sharply diminished the immune response of mice to subsequent injections of an effective Group C vaccine. The precipitin reactions of these substances with an equine polyvalent antimeningococcal serum prepared in 1918 indicated that Group C meningococci had been isolated in the United States at that time, although they were not recognized as a distinct group until 1940.

Footnotes

This investigation was supported by U. S. Public Health Service grants E-597, National Microbiological Institute, and D-346, National Institute of Dental Research.

² Taken from a thesis submitted by R. Glenn Watson to the University of Rochester in partial fulfillment of the requirements for the degree, Doctor of Philosophy. Present address: Department of Microbiology and Immunology, The Bowman Gray School of Medicine of Wake Forest College, Winston-Salem, N. C.