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Antigenic Variation in Relation to Classification of Shigella Flexneri^*

From the Department of Bacteriology, 406th Medical General Laboratory, APO 343, Postmaster, San Francisco, California, and The Department of Chemistry, Defense Academy, Japanese Self-Defense Forces, Yokosuka, Japan

Abstract

1. A technique to introduce phase variations of Shigella flexneri by means of antiserum was established studying various S. flexneri strains.

2. The pathways of the antigenic degradation of S. flexneri were traced using this method, and the resulting variations were discussed in relation to classification of S. flexneri species.

Footnotes

^* Part of this work was supported by Contract No. DA-92-557-FEC-23928 with the U. S. Army, Far East, as an investigation in the preparation of specific monovalent sera.