HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Dimopoullos, G. T. Articles by Fellowes, O. N. Search for Related Content PubMed PubMed Citation Articles by Dimopoullos, G. T. Articles by Fellowes, O. N.

Electrophoretic Composition and Antibody Studies of Anti-Foot-and-Mouth Disease Guinea Pig Serum

From the Plum Island Animal Disease Laboratory, Animal Disease and Parasite Research Division, Agricultural Research Service, U. S. Department of Agriculture, Greenport, L. I., New York

Abstract

1. Anti-foot-and-mouth disease guinea pig serum was subjected to paper electrophoretic analyses using horizontal and vertical continuous-flow techniques.

2. Analyses of whole immune sera for protein composition revealed no significant differences when compared with normal sera.

3. No relationship was demonstrated between protein composition, virus-neutralizing and complement-fixing antibody titers.

4. In fractions of sera tested for virus-neutralizing antibody activity, the - and -globulins were capable of neutralizing all of the virus infectivity.

5. Complement-fixing activity was found only in the -globulin fraction of highest mobility.

6. Evidence is presented that the complement-fixing and virus-neutralizing antibodies are two distinct antibodies.

Footnotes

¹ Present address: Department of Veterinary Science, Louisiana State University, Baton Rouge, Louisiana.