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Studies on Toxoplasmosis

II. Toxoplasma Antibodies in Obstetrical Patients with Extensive Serological Follow-up¹

From the Minnesota Department of Health, Division of Medical Laboratories, Minneapolis, Minnesota and Hutchinson, Minnesota

Abstract

1. In an unselected group of 327 obstetrical patients the dye test for toxoplasma antibodies was positive in 31.5%.

2. Serological follow-up on 272 (84.2%) patients, with an average of 2.9 specimens per person, covered a median of 55 months and indicated the following: a) The rate of change from negative to positive was 5.1% during the study period or about 1.0% per year. b) Only one of 88 patients with dye test positive in dilution 1:4 or higher changed to dye test negative during the study period. c) Significant increase in titer (16-fold rise) was observed in only 3 of the 88 dye test positive patients, and may signify antigenic stimulation from re-exposure or ruptured pseudocysts.

Footnotes

¹ This investigation was supported in part by a research grant E-1035 from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Public Health Service.