HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Fisher, M. W. Articles by Manning, M. C. Search for Related Content PubMed PubMed Citation Articles by Fisher, M. W. Articles by Manning, M. C.

Studies on the Immunotherapy of Bacterial Infections

I. The Comparative Effectiveness of Human -Globulin Against Various Bacterial Species in Mice

From the Research Laboratories, Parke, Davis & Company, Detroit, Michigan

Abstract

Pooled human -globulin exhibited therapeutic activity in mouse infections induced with a variety of bacteria, with this action being related to the dose of -globulin. In order of decreasing susceptibility were strains of Staphylococcus aureus, Pseudomonas aeruginosa, Proteus vulgaris, Escherichia coli, Streptococcus salivarius, Streptococcus pyogenes and Diplococcus pneumoniae. Slight activity was noted against Salmonella typhimurium. The bacteria not affected by -globulin were Klebsiella pneumoniae, Pasteurella multocida and Streptococcus species, Group C. These findings appear to be consistent with the concept that normal antibodies are responsible for the described in vivo activity of -globulin.