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Persistence of Circulating Antibodies in Human Subjects Immunized with Dextran, Levan and Blood Group Substances¹

From the Departments of Microbiology and Neurology, College of Physicians and Surgeons, Columbia University, and the Neurological Institute, Presbyterian Hospital, New York, New York

Abstract

Persistence of circulating precipitins to blood group A substance, dextran and levan, were followed in a small number of individuals over a period of years. Despite the presence of amino acids in blood group A substance, anti-A showed a persistence pattern comparable to pneumococcal anticarbohydrate, antidextran and antilevan. Three anti-A sera and 2 antidextran sera showed a decline in antibody level from to peak values over a period of about 3 years, with the subsequent maintenance of these levels of circulating antibody N for a period of 1 to 9 years.

Footnotes

These studies were supported by the Office of Naval Research, Navy Department, Washington, D. C., the National Science Foundation (NSF G-1586) and the William M. Matheson Commission. Reproduction in whole or in part is permitted for any purpose of the United States Government.

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