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Elimination of Nonspecific Components from Viral Antigens by Fluorocarbon¹

From the Division of Virology, The Department of Public Health and Preventive Medicine, School of Medicine, The University of Pennsylvania and the Children's Hospital, Philadelphia, Pennslyvania

Abstract

Several viral complement fixing antigens derived from various host systems were treated with fluorocarbon. It was possible to remove undesirable reactivities such as anticomplementary activity and host component antigens from these preparations.

The specific complement fixing antigens demonstrated differences in their susceptibilities to the fluorocarbon treatment. Those of the Coxsackie and poliomyelitis groups tolerated successive treatments without loss in titers. Others, i.e., mumps and influenza virus (V) and soluble (S) antigens, were precipitated after 2 treatments.

Footnotes

This work was supported by a grant-in-aid from the National Institutes of Health, U. S. Public Health Service.

² On leave of absence from the Kinderklinik, Universitätskrankenhaus, Hamburg-Eppendorf. Fellow of the Deutsche Gesellschaft Zur Erforschung Der Kinderlähmung.