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The Effect of Feeding Simple Chemical Allergens to Pregnant Guinea Pigs upon Sensitizability of Their Offspring¹

From the Department of Dermatology and Syphilology of the New York University Postgraduate Medical School; and the Skin and Cancer Unit of the University Hospital New York, New York

Abstract

Pregnant guinea pigs were fed solutions of picryl chloride (PC) or dinitrochlorobenzene (DNCB) during part of their gestation period. The offspring born to these animals had a slightly, though consistently, lower capacity to become sensitized to the homologous allergen than did the offspring born to mothers not fed the allergen. This slight effect appeared to be specific, since it did not extend to sensitizability to citraconic anhydride (CA), a chemically unrelated allergen.

Footnotes

This study was supported by a grant from the United States Public Health Service (e-1361 (C2)).