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The Journal of Immunology, 1958, 80: 407-414.
Copyright © 1958 by The American Association of Immunologists, Inc.
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Chick Potency Tests of Poliomyelitis Vaccine: Basic Studies on Response1

E. A. Timm, E. Z. Rope, I. W. McLean, Jr., Barbara Ternan and Mary Bernardi

From the Research Laboratories of Parke, Davis and Company, Detroit, Michigan

Abstract

Results have been presented which show that baby chicks respond with neutralizing antibodies to injections of poliovirus preparations and provide an excellent method for antigenic potency testing of such preparations. The relative merits of 1-dose and 2-dose schedules, and the merits of serum titers as opposed to antigen extinction titers have been discussed.

Footnotes

1 Presented in part at the Annual Meeting of the Federation of American Societies for Experimental Biology, Chicago, Illinois, April 16, 1957.






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