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Treatment of Poliomyelitis in Monkeys with Hyperimmune Rabbit -Globulin

From the Wyeth Laboratories Inc., Philadelphia, Pennsylvania and the South Jersey Medical Research Foundation, Camden, New Jersey

Abstract

Hyperimmune antipoliovirus rabbit -globulin has been prepared which contains up to 200-fold more neutralizing antibody/unit volume than human Red Cross -globulin. When given to man these antibodies could not be detected in the cerebrospinal fluid in one patient.

Used in therapy of type 1 (Mahoney) poliomyelitis in rhesus monkeys, the rabbit -globulin protected a small percentage of the monkeys and was superior to human -globulin. It was most effective when given at the time of intramuscular challenge of the monkeys, probably less effective after an interval of 24 or 48 hr and not effective if given after paralysis was apparent.