HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kaplan, M. H. Articles by Swift, A. Search for Related Content PubMed PubMed Citation Articles by Kaplan, M. H. Articles by Swift, A.

Immunologic Studies of Heart Tissue

II. Differentiation of a Myocardial Sarcoplasmic Antigen and Cardiolipin¹

From the House of the Good Samaritan, Children's Medical Center, and Department of Bacteriology and Immunology, Harvard Medical School, Boston, Massachusetts

Abstract

An alcohol-extractable sarcoplasmic antigen previously identified in the hearts of several mammalian species, may be differentiated from cardiolipin by absorption and immunohistochemical tests. Antibody titers to these 2 antigens were found to vary independently in sera of rabbits immunized with homogenates of beef heart or rat heart tissue. Absorption of these sera with cardiolipin did not remove antibody to the sarcoplasmic antigen, while absorption with heart tissue homogenate removed both antibodies. Both antigens are constituents of the myocardial cell sarcoplasm; however, differences in their histochemical properties can be demonstrated.

Footnotes

¹ This work was performed under grants-in-aid from the American Heart Association and from the National Institutes of Health (H-1763).

² This work was done during the tenure of an Established Investigatorship of the American Heart Association.

Present address: Department of Medicine, Cleveland City Hospital, Western Reserve University School of Medicine, Cleveland, Ohio.