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Studies on Hemagglutination with Herpes Simplex Virus¹

I. Adsorption Studies As Evidence That the Antigen-Antibody Reaction Is Specific and the Neutralizing and Hemagglutinating Antibodies Are Identical

From the Department of Microbiology, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma, and Laboratory Service, Veterans Administration Hospital, Oklahoma City, Oklahoma

Abstract

The antibody in herpes simplex immune serum can be removed by adsorption with tannic acid treated and virus sensitized sheep erythrocytes.

The removal of this antibody as demonstrated by both hemagglutination and infectivity techniques indicate that the herpes simplex neutralizing and hemagglutinating antibodies are probably identical and that a specific antigen-antibody reaction is involved in the hemagglutination test with herpes simplex virus.

Footnotes

This investigation was supported in part by a research grant (B-964C) from the National Institutes of Neurological Diseases and Blindness, U. S. Public Health Service.