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The Reaction of Dog Intestinal Phosphatase with its Antibodies in the Region of Excess Antibody¹

From the Research Biochemistry Section, Sloan-Kettering Institute for Cancer Research, New York, New York, and the Division of Research Biochemistry, Roswell Park Memorial Institute for Cancer Research, Buffalo, New York

Abstract

The nature of the precipitin reaction of dog intestinal phosphatase with its rabbit antiserum have been investigated with special emphasis on the region of excess antibody. Evidence for the existence in this region of soluble antigen-antibody complexes has been presented and discussed.

The use of horse antibodies against rabbit -globulin has been demonstrated to be useful for detecting and studying soluble complexes of antigen and antibody. The use of horse antibodies for the quantitative precipitation of phosphatase at levels estimated to be below 1 is described.

Footnotes

¹ A preliminary report on this work has appeared elsewhere (1).

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