HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Hartman, J. D. Articles by Schreck, K. M. Search for Related Content PubMed PubMed Citation Articles by Hartman, J. D. Articles by Schreck, K. M.

The in Vitro Quantitative Relationship between Two Systems Affecting Blood Leukocytes in Inflammatory Hypersensitivity Reactions Resulting from Different Antigens¹

From the Department of Anatomy, and the Department of Microbiology, Temple University School of Medicine, Philadelphia, Pennsylvania

Abstract

1. Leukocyte agglutination has been demonstrated to occur in the presence of microgram quantities of antigenic agents in blood from both sensitive and nonsensitive animals. The amount necessary to produce the leuko-agglutinating response is from 10 to 100 times more in blood from nonsensitive animals.

2. The leuko-agglutinating response has been produced with egg albumin, -globulin, and pneumococcal polysaccharide.

3. A heat stable, nondializable factor which can produce leukocyte agglutination has been identified in the water soluble serum globulin fraction from animals with inflammation.

4. This factor when diluted 1/2000 to 1/5000 is still able to accentuate and at least in certain instances reduce the threshold of the leuko-agglutinating response to the 3 unrelated antigens.

5. The Inflammatory Leukocyte Agglutinating Factor is inhibited by hydrocortisone, whereas, the action of antigen in the leuko-agglutinating system is not.

Footnotes

¹ This investigation was supported by Research Grant E-1360 from the National Institute of Allergy and Infectious Diseases, Public Health Service.