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The Immune Response of the Guinea Pig to the Antigens of Pasteurella Pestis¹

George Williams Hooper Foundation, University of California, San Francisco, California, and Department of Microbiology, Boston University School of Medicine, Boston, Massachusetts

Abstract

In experimental antiplague immunization the reaction of the guinea pig has been unique. Of greatest interest have been the difficulties in immunizing this animal either with aqueous suspensions of killed plague bacilli or with antigenic extracts of Pasteurella pestis, both highly immunogenic in the mouse, rat and monkey. The report that follows is an account of the development of the present conclusions about the immune response of this animal.

Materials and Methods. Strains of P. pestis. 1) Yreka, a virulent strain originally isolated from a fatal human infection in Yreka, California. 2) 195/P, a virulent strain from the Haffkine Institute in Bombay, India. It was originally isolated from a fatal pneumonic plague infection, and a sample of the culture was lyophilized and shipped to the Hooper Foundation. 3) Shasta, a virulent strain isolated from a fatal bubonic infection in 1951. 4) 111, a virulent strain isolated from a fatal pneumonic infection in Madagascar.

Footnotes

¹ This work was sponsored in part by the Commission on Immunization, the Armed Forces Epidemiological Board; the National Institutes of Health, U. S. Public Health Services; the Division of Communicable Disease, Walter Reed Army Institute of Research; and the University of California.