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Hepatic Reactions in Anaphylaxis

V. Mechanism of the Increased Hepatic Resistance During Canine Peptone Shock

From the Laboratory of Bacteriology and Experimental Pathology, Stanford University, California

Abstract

1. The dominant factor increasing resistance to blood flow through the liver during canine peptone shock is a suddenly increased permeability of the sinusoidal endothelium.

2. This produces an explosive hepatic edema accompanied by swelling of the parenchymatous cells, increasing local tissue pressure sufficient to cause passive sinusoidal vasoconstriction and passive constriction of the hepatic veins.

3. The sudden loss of fluid from the sinusoidal blood increases local blood viscosity sufficient to cause temporary sinusoidal stasis, and even stasis in the narrowed hepatic veins.

4. A minor factor contributing to this increased resistance, is sinusoidal narrowing from leucocytic deposits.

5. We have no evidence thus far that active hepatic vasoconstriction is a factor in this reaction.