HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Chen, B.-L. Articles by Ling, C.-F. Search for Related Content PubMed PubMed Citation Articles by Chen, B.-L. Articles by Ling, C.-F. Pubmed/NCBI databases Medline Plus Health Information Diphtheria Tetanus Whooping Cough

Studies on Diphtheria-Pertussis-Tetanus Combined Immunization in Children

III. Immune Responses After the Booster Vaccination¹

From the Standardization Section, Taiwan Serum Vaccine Laboratory, Shihling, Taipei, Taiwan

Yao-Tung Wang, Hsiu-Hua Ko, Wang-Cheng Huang and Che-Fu Ling

From the Provincial Health Education and Training Center, Taipei, Taiwan

Abstract

A group of 68 children was given a booster dose of 0.5 or 0.2 ml of DPT vaccine 11–15 mo after the primary vaccination. The serum antibody content of the three systems titrated 30–45 days after booster injection showed that all the children were adequately protected according to generally accepted criteria.

Over the range of prevaccination titers studied, a rectilinear relationship was shown to exist in all the three systems between the log prevaccination titer and the log fold-increase in titer after booster injection. The slopes of the 0.2-ml dose were steeper than those of the 0.5-ml dose, moving beyond the hypothetical positions toward the higher initial titer side. The departure was ascribed to the interference effect of high levels of pre-existing antibodies upon the homologous antigens introduced.

Some general problems in secondary immunization like the dose-response relationship, the comparison between groups, and the choice of use of large versus small dose, etc., were discussed in the light of the observations made.

Footnotes

¹ With the technical assistance of Mr. Chao-Meng Kung, Taiwan Serum Vaccine Laboratory.