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Studies of Antibodies Against Organ-Antigens

I. Effects of anti-Mouse Spleen Serum Upon the Reticuloendothelial System

From the Divisions of Microbiology and Physiology, New England Institute for Medical Research, Ridgefield, Connecticut

Abstract

Antimouse spleen serum exerted a pronounced effect upon mice as evidenced by ruffled fur, apathy and splenomegaly with histologic changes in the spleen elements. The antiserum did not, however, significantly affect the uptake from the circulation of the colloidal carbon by the RES of the mouse. Substitution of CrP³²O₄ for the carbon revealed that the spleens of the mice treated with AMSS contained at least twice as much radioactive colloid as spleens of the control mice. The increased uptake might be due to either the preferential stimulation of the spleen RES by the AMSS or by the spleen hyperplasia or by both.