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A Study of Experimental Encephalomyelitis Employing Mammalian and Nonmammalian Nervous Tissues¹

From the Department of Microbiology, University of Virginia, School of Medicine, Charlottesville, Virginia

Abstract

Three species of nonmammalian nervous tissue (frog, snake and turtle) failed to elicit experimental encephalomyelitis in the Hartley guinea pig, in contrast to the known and demonstrable paralytogenic activity of rabbit brain for this host.

Both mammalian (rabbit) and nonmammalian (frog, snake and turtle) nervous tissues stimulated the production of CF antibrain antibodies in rabbits. Such antibodies cross reacted with and could be absorbed by either mammalian or nonmammalian brain. Thus, it is concluded that the CF antibrain antibodies are stimulated by at least one antigenic component common to both mammalian and nonmammalian nervous tissue.

Both mammalian and nonmammalian brain tissues elicited CF antibodies; only mammalian brain produced paralysis. Thus, these CF antibrain antibodies appear to be directed against an antigen(s) of a nonparalytic character and would appear to play no direct role in initiating encephalopathy.

Footnotes

¹ This investigation was supported by a research grant (B890) from the National Institutes of Health, Public Health Service, and by the Fluid Research and Development Fund of the School of Medicine, University of Virginia.

² This work was done during the tenure of an Established Investigatorship of the American Heart Association.