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Cross Reactions of Polyglucoses in Antipneumococcal Sera

IV. PRECIPITATION IN RABBIT ANTISERA TO TYPE IX AND TYPE XII PNEUMOCOCCUS¹

From the Institute of Microbiology, Rutgers, The State University, New Brunswick, New Jersey the Department of Medicine, College of Physicians and Surgeons, Columbia University, and the Presbyterian Hospital, New York

Abstract

The cross reactivity of Types IX and XII antipneumococcal rabbit sera toward glycogen, a limit dextrin, and a fraction of synthetic polyglucose is described and related in a measure to the chemical constitution of these carbohydrates.

The precipitation of antibody by glycogen and limit dextrin is reversed by the action of amylase present in the sera, but conditions are given for minimizing the effects of the enzyme.

Footnotes

¹ The work reported in this communication was carried out under the Harkness Research Fund of the College of Physicians and Surgeons, Columbia University, and grants from the Rockefeller Foundation and National Science Foundation to Columbia University and Rutgers University, respectively.

² Present address, Institute of Microbiology, Rutgers University, New Brunswick, New Jersey.

³ Fulbright Fellow from University of Marburg, Germany.

⁴ Present address, Roswell Park Memorial Institute, Buffalo, N. Y.