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Cross Reactions of Polyglucoses in Antipneumococcal Sera

III. REACTIONS IN HORSE SERA^1,2,

From the Department of Medicine, College of Physicians and Surgeons, Columbia University, the Presbyterian Hospital, New York and the Institute of Microbiology, Rutgers, The State University, New Brunswick, New Jersey

Abstract

1. A synthetic polyglucose fraction is shown to precipitate more antibody nitrogen from Types II, IX, XII, XX, and XXII antipneumococcal horse sera than do various glycogens, amylopectins, and other natural polyglucoses. Quantitative data are given.

2. Various features of these cross reactions and the compositions of certain of the precipitates are discussed.

3. Use is made of the action of amylase on glycogen-antibody precipitates for the partial purification and concentration of cross-reactive antibody.

4. Preliminary results are given with an analytical method which appears to provide a new criterion of homogeneity for carbohydrates composed of a single sugar or polysaccharides not fractionated by a single precipitation with an antiserum.

Footnotes

¹ For papers I and II, see References 1 and 5.

² The work reported in this communication was carried out in part under the Harkness Research Fund of Columbia University, in part under grants to Columbia University from the Rockefeller Foundation and the Armed Forces Epidemiological Board, and in part under a grant from the National Science Foundation to Rutgers University.

³ Institute of Microbiology, Rutgers University, New Brunswick, New Jersey.

⁴ Fulbright Fellow at Rutgers University from the Department of Medicine, University of Marburg, Germany. Now at the University of Munich.

⁵ Wallenberg and Swedish Cancer Society Fellow at Columbia University, from the State Bacteriological Institute, Stockholm. Sweden.