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Intracellular Localization of Tobacco Mosaic Virus in Mouse Liver

Radioisotope and Research Services, Wadsworth General Hospital, Veterans Administration Center, and the Department of Radiology, School of Medicine, University of California, Los Angeles

Abstract

Localization of intravenously injected radioactive TMV in mouse liver has been studied by cellular fractionation and electron microscopy.

TMV uptake by the mitochondria as measured by radioactivity has been confirmed by electron microscopy of the isolated fractions.

No evidence was obtained for the localization of TMV in the nuclei of any cell types.

Electron microscopy of thin sections revealed aggregates of TMV only within vacuoles of Kupffer cells. Failure to detect TMV in sections of mitochondria is explained in terms of lack of sensitivity of the method.