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In Vivo Uptake of Isotope-Tagged Tuberculin by Leukocytes¹

From the Departments of Medicine, the Peter Bent Brigham Hospital and Harvard Medical School, Boston, Massachusetts, and the Palo Alto Medical Research Foundation, Palo Alto, California

Abstract

1. PPD has been tagged with I¹³¹ without altering its biological potency.

2. The fate of I¹³¹-tagged PPD given intravenously to normal rabbits has been followed by measuring radioactivity found in plasma and on the leukocytes and erythrocytes of these animals during the subsequent 24 hours.

3. I¹³¹-tagged PPD is partially cleared from the plasma during the first 24 hours after injection. It is firmly absorbed to the leukocytes during the first 4 hours after injection. No tag is found on leukocytes after 4 hours.

4. The significance of leukocyte uptake of a tagged bacterial protein is discussed.

Footnotes

¹ This study was supported by U. S. Public Health Service Grant E32-(C5 and C6) and the 20–30 Fund of the 20–30 Foundation, Sacramento, California.

² Postdoctorate Fellow of the Life Insurance Medical Research Fund.

³ Present address: The Rockefeller Institute for Medical Research, New York 21, New York.

⁴ Present address: Palo Alto Medical Research Foundation, Palo Alto, California.