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Inhibition of the Local Shwartzman Reaction by Dicumarol¹

From the Laboratory of Hematology, Instituto Butantan, São Paulo, Brasil

Abstract

Dicumarol was given to rabbits in amounts sufficient to lower the prothrombin time level below 1%; this treatment inhibits the local Shwartzman reaction.

Temporary thrombocytopenia occurs in Dicumarol-inhibited Shwartzman-negative rabbits, in Shwartzman-positive animals, and also after a single intravenous injection of Serratia marcescens toxin, without previous dermal preparation (sensitization). There was no direct relation between the fall of platelets in the peripheral blood and the appearance or nonappearance of a positive Shwartzman reaction.

Footnotes

¹ This work was supported by a fund from the Conselho Nacional de Pesquizas.

² From the Department of Pathological Anatomy and Clinic for Infectious and Tropical Disease of the Faculdade de Medicina de São Paulo, São Paulo, Brasil.

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