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Role of Host Defenses in Systemic Klebsiella Pneumoniae Infection: Effect of Antibiotics in Normal and X-Irradiated Mice^1,2,

From the Department of Bacteriology, College of Medicine, University of Utah, Salt Lake City, Utah

Abstract

No bacteremia was observed in adult albino Mus musculus for 10 days following exposure to 350 r (LD_{0/30 days}) of total body irradiation. The natural resistance of such irradiated mice to intraperitoneally induced Klebsiella pneumoniae infection was significantly depressed on the first, second, fourth and ninth post-irradiation days when the animals were challenged. The significance of host defense participation in recovery from the experimental infection was inferred from the greater mortality among irradiated and treated mice than among non-irradiated and treated control animals. The critical significance of the cellular defense mechanisms of the albino mouse has been discussed.

Footnotes

¹ Work reported in this paper was carried out under research grants from the Division of Research Grants and Fellowships, National Institutes of Health, United States Department of Health, Education and Welfare.

² Presented before the American Association of Immunologists, 38th Annual Meeting, Atlantic City, 1954.