HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Ledinko, N. Articles by Perry, B. Search for Related Content PubMed PubMed Citation Articles by Ledinko, N. Articles by Perry, B.

Studies with Influenza Virus B of Recent Human Origin

I. Adaptation to the Mouse Lung

From the Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia

Abstract

1. The biphasic course of adaptation to the mouse lung of a type B influenza virus of recent human origin is described. Inoculation of the virus resulted in the production of extensive pulmonary consolidation and multiplication of virus as determined by hemagglutinin and egg infectivity titrations of bronchial washings. Continued passage resulted in a gradual decrease in consolidation and a depression of multiplication resulting in no demonstrable hemagglutinin and a decrease in egg infectivity titer. A subsequent gradual rise in consolidation and an increase of hemagglutinin and egg infectious particles were found. During the early phases of adaptation, a "functionally deficient" form of virus was produced.

2. A study of the character of the lesion-producing capacity of the unadapted virus revealed that (a) the extent of lung lesions obtained paralleled the dosage of virus inoculated, and (b) the extent of consolidation produced was found to correlate with the production of hemagglutinin units.

3. Continued passage in the chick embryo resulted in a diminished ability of unadapted virus, upon introduction into the mouse lung, to multiply and to produce consolidation.

Footnotes

¹ Fellow of the National Foundation for Infantile Paralysis.

² This work was aided by a grant from the National Health and Medical Research Council, Canberra. A.C.T. Australia.