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Antibody Production by Spleen in Vitro

II. Correlation of Qeight of Rabbit, Qeight of Spleen, and Level of Antibody Produced in Vitro¹

From the Westchester County Department of Laboratories and Research, Valhalla, New York²

Abstract

Eleven rabbits of the same breed but of various weights were given each a single intravenous injection of typhoid vaccine. Four days later, the weight of the spleen and the weight of the rabbit showed a positive correlation. Furthermore, the weight of the spleen (as well as the weight of the rabbit) showed a positive correlation with an index of the antibody-forming capacity of a given mass of the spleen in vitro.

Footnotes

¹ This investigation was supported by Research Grant no. E-523 from the National Microbiological Institute, the National Institutes of Health, United States Public Health Service.

² Present address: The Babies Hospital, Columbia-Presbyterian Medical Center, New York 32, N. Y.