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Persistence of Rickettsia Rickettsii in a Patient Recovered from Rocky Mountain Spotted Fever^1,2,

From the Section of Infectious Diseases, Department of Medicine, University of Maryland School of Medicine and the University Hospital, Baltimore, Maryland

Abstract

Viable rickettsiae were isolated from the lymphatic tissues of a patient one year following recovery from Rocky Mountain spotted fever. The recovered agent was maintained by serial passage in guinea pigs and fertile hens' eggs. Identity of the isolated agent was established by:

1. The development of specific complement fixing antibodies in guinea pigs.

2. Direct visualization of the microorganisms in yolk sac tissues.

3. The demonstration of its ability to afford cross immunity to a standard laboratory strain of R. rickettsii.

Footnotes

¹ This study was supported by a grant-in-aid to the Section of Infectious Diseases from the Parke, Davis Company, Detroit, Michigan.

² Presented at the Annual Meeting of the American Federation for Clinical Research, Atlantic City, May 3, 1953.

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