HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Benacerraf, B. Articles by Halpern, B. N. Search for Related Content PubMed PubMed Citation Articles by Benacerraf, B. Articles by Halpern, B. N.

The Effect of Histamine Upon the Local Fixation of Antibodies in the Skin of the Guinea Pig

From the Laboratory of Experimental Medicine of the Clinique Medicale Propedeutique de l'Hôpital Broussais (Prof. Pasteur Vallery-Radot) and Centre National de la Recherche Scientifique, Paris

Abstract

The latent period of sensitization of passive cutaneous anaphylaxis of the guinea-pig is inversely proportional to the amount of antibody injected intravenously to sensitize the animal.

The injection of very small doses of histamine intradermally, or the local treatment with mild irritants, can bring about preferentially the appearance of the reaction of passive cutaneous anaphylaxis at the treated site; small doses of histamine or other mild inflammatory agents are therefore able to bring about the local fixation of circulating antibody.