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The Uptake of Radioactive Phosphorus by Mouse Lymph Nodes During Sensitization to a Foreign Protein¹

From the Richard Cohn Radiobiology Laboratory, Detroit Institute of Cancer Research, and Wayne University College of Medicine, Detroit, Michigan

Abstract

Changes in weight, histologic structure, and uptake of radioactive phosphorus in the lymph nodes of mice were examined and correlated with precipitin titers in the blood serum following first and second injections of horse serum. The results of the study indicate that phosphorus turnover in lymph nodes of normal mice is intimately and specifically associated with immunization processes taking place in the animals.

Footnotes

¹ Supported in part by grant number C-2151 from the National Cancer Institute of the National Institutes of Health, U. S. Public Health Service and in part by institutional grants to the Detroit Institute of Cancer Research from the American Cancer Society, Inc., The American Cancer Society, Southeastern Michigan Division, and The Kresge Foundation.