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The Half-Life of I¹³¹ Labeled Normal Human Gamma Globulin in Patients with Hepatic Cirrhosis¹

From the Jefferson Medical College, Philadelphia, Pa.

Abstract

The half-life of normal human gamma globulin labeled with I¹³¹ was determined in sixteen patients with hepatic cirrhosis and in seventeen controls.

In the patients with cirrhosis the mean half-life measured 9.1 days, and in the controls it was 13.7 days. This difference was statistically highly significant.

These results are interpreted as supporting the concept that the accumulation of gamma globulins in patients with hepatic cirrhosis is due to increased production rather than delayed removal.

Footnotes

¹ Sponsored by the Commission on Liver Diseases, Armed Forces Epidemiological Board, and supported in part by the Office of The Surgeon General, Department of the Army.