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Antibody Response of Suckling Mice to Mumps Virus

II. RELATION OF ONSET OF ANTIBODY PRODUCTION TO SUSCEPTIBILITY TO MUMPS VIRUS INFECTION

From the Laboratory of Infectious Diseases, National Microbiological Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education of Health, Education, & Welfare

Abstract

1. Development of resistance of suckling mice to mouse adapted mumps virus, as the age on inoculation increases, correlates with improvements in ability to form antibody as the mice mature.

2. Mice 3 days of age on inoculation are partially susceptible to mumps virus in that about 35% die, 20% become ill but recover, and the remainder fail to show sign of disease at any time. Antibody levels of the mice well at the end of the incubation period are consistently higher than mice sick at this interval after virus inoculation.

3. Passive immunization of mumps-infected newborn mice affords complete protection to animals which do not ordinarily survive the infection.

Footnotes

^* Present Address: The Rockefeller Institute for Medical Research, New York City.