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Antibody Response of Suckling Mice to Mumps Virus

I. IMMUNE RESPONSE FOLLOWING IMMUNIZATION WITH MUMPS VIRUS VACCINE

From the Laboratory of Infectious Diseases, National Microbiological Institute, National Institutes of Health, Public Health Service, U. S. Department of Health, Education, & Welfare

Abstract

Studies of the antibody response of mice from birth to maturity following immunization with mumps virus vaccine are described. Results of serial anti-hemagglutinin determinations following a single dose of antigen indicate a transitory antibody response in mice 5–7 days of age when inoculated. A gradual improvement in antibody production is demonstrable as the age on immunization is increased until a mature response is observed in mice 14 days of age. This relation of age and immune response is confirmed by experiments in which the magnitude of the secondary response was determined in mice which received the initial dose of antigen from 1 to 14 days of age. Other experiments indicate that adult mice respond to amounts of mumps virus antigen which evoke no detectable antibody response in mice 10 days of age when inoculated.

Footnotes

^* Present Address: The Rockefeller Institute for Medical Research, New York City.