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Antigenic Relations of Blood Group Antigens as Suggested by Tests with Lectins¹

From Boston University, School of Medicine, Boston 18, Massachusetts

Abstract

An examination of some of the unusual specificities exhibited by certain plant agglutinins (lectins) suggests considerable chemical and antigenic similarities among the A₁, A₂, B and O (H) blood group substances. These lectins are also capable of acting as specific precipitins, and analysis of precipitates made with specific substances shows that purification by ethanol-water fractionation has produced preparations of which over 30% of the nitrogen is specifically active. Practical application of some of these preparations in the routine diagnosis of subgroups is suggested.

Footnotes

¹ The work reported in this paper was made possible by support extended to Boston University by the United States Atomic Energy Commission, under Contract no. AT(30-1)-1395, by the Navy Department (Office of Naval Research) under contract no. Nonr-492 (01) and by a research grant (H-1076) (2)) from the National Heart Institute, National Institutes of Health, Public Health Service.