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The Journal of Immunology, 1954, 73: 221-225.
Copyright © 1954 by The American Association of Immunologists, Inc.
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The Development of Resistance in Mice Immunized with Soluble Antigen Derived from Bacterium Tularense

Carl L. Larson, J. Frederick Bell and Cora R. Owen

From the U. S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Microbiological Institute, Rocky Mountain Laboratory, Hamilton, Montana

Abstract

White mice immunized with soluble antigens obtained from B. tularense showed specific resistance to challenge within 24 hours after immunization and developed circulating, protective antibodies within 72 hours. Mice so immunized failed to develop detectable agglutinins.






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