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An Unidentified Antibody in Anti-Egg Albumin Sera Revealed by the Agar Diffusion Technic

METHODS FOR ITS IMMUNOCHEMICAL ANALYSIS¹

From the Departments of Neurology and Microbiology, College of Physicians and Surgeons, Columbia University and the Neurological Institute, Presbyterian Hospital, New York

Abstract

A previously unidentified antibody in anti-egg albumin sera, designated anti-EW_x, has been shown to give a characteristic precipitin curve. Data are presented to suggest that its specific antigen, EW_x, constitutes less than 1% of the total protein of egg white. The presence of the antibody in anti-egg white sera and its absence in anti-conalbumin sera has been demonstrated.

The significance of examining sera for antibody to impurity by multiple methods is illustrated and the limitations of such methods when used singly are discussed.

Footnotes

¹ This work was supported by a grant (B-9) from the National Institutes of Neurological Diseases and Blindness of the National Institutes of Health, Public Health Service and by the William J. Matheson Commission.

² National Research Council Fellow in Medical Sciences, 1951–1953. Present address: Department of Medicine, Medical College of Virginia, Richmond.