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Studies on the Complement Function

II. THE DUAL ACTIVITY OF COMPLEMENT^1,2,

From the Division of Laboratories and Research, New York State Department of Health, Albany

Abstract

1. Changes in the degree of sensitization of the erythrocytes or of the hemolysis time are shown to affect the activities of several complement solutions to different extents. These peculiarities are attributed to differences in the C component ratios of the solutions.

2. It is suggested that two functional activities are involved in C interactions, one taking part in fixation and the other involved in a subsequent hemolytic attack on the erythrocyte. The apparent anomalies in C activity are attributed to the interactions of these two agents.

Footnotes

¹ Taken in part from a thesis presented, in partial fulfillment of the requirements for the degree of Doctor of Philosophy, to the Faculty of Rensselaer Polytechnic Institute, Troy, New York.

² Presented in part before the American Association of Immunologists, Atlantie City, New Jersey, April 13, 1954.