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Electrophoretic Mobility in Paper of Isoagglutinins

From the Department of Medicine, Stanford University, San Francisco, California

Abstract

The electrophoretic mobility of the isoagglutinins has not been extensively studied. Two publications bear on this subject; both, however, depend partially on chemical methods and both used pooled rather than individual sera.

Enders (1) in 1944, using fractions prepared by the methods of Cohn et al. found most of the isohemagglutinin and typhoid ‘O’ agglutinin activity in Fraction III-1 while he found most bacterial and viral antibodies and a lesser amount of isoagglutinin in Fraction II. Fraction II is 95% -globulin. Fraction III-1, with the bulk of the isoagglutinin, is 25% -globulin, 70% -globulin and 3% -globulin. In this work, Enders was not primarily interested in the electrophoretic mobility of the isoagglutinins but he did report the electrophoretic patterns of the fractions. He pointed out that these data did not establish whether the isoagglutinins were in the -, - or -globulin fraction but suggested that if they were associated with -globulins, these were probably different from the -globulins of Fraction II which contain many exogenously stimulated antibodies.