HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Silverman, M. S. Articles by Chin, P. H. Search for Related Content PubMed PubMed Citation Articles by Silverman, M. S. Articles by Chin, P. H.

Quantitative Serological Determination of Antibody Formation in X-Irradiated Rabbits¹

From the Biological and Medical Sciences Division, U. S. Naval Radiological Defense Laboratory, San Francisco 24, California

Abstract

Four hundred roentgen whole body X-irradiation inhibited the primary antibody response of rabbits when exposure occurred 24 hours before the injection of crystalline egg albumin emulsified in Freund's adjuvant.

Even though the antigen was administered with adjuvant, which presumably permitted a prolonged, slow antigenic stimulation, the response of the irradiated animals never equaled that of the non-irradiated animals even after 27 weeks when recovery from radiation injury could be presumed to have occurred. However, a secondary rise in antibody nitrogen did occur in 3 out of 5 rabbits 14 to 23 weeks after immunization.

Exposure to X-irradiation 24 hours prior to the administration of a second injection of antigen had no effect on the specific anamnestic reaction.

Footnotes

¹ Supported in part by the Office of Naval Research, Department of the Navy.

² The opinions or assertions contained herein are those of the authors and are not to be construed as official or reflecting the views of the Navy Department or of the Naval Service at large.

³ The authors gratefully acknowledge the technical assistance of John C. Young, HM1, USN.