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Inhibition of Antibody Formation in Mature Rabbits by Contact with the Antigen at an Early Age

From the U. S. Department of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Microbiological Institute, Laboratory of Infectious Diseases, Bethesda, Md.

Abstract

Rabbits subjected to early immunization with bovine serum albumin failed to develop antibody to bovine serum albumin either during the initial immunization or when mature. Evidence was also obtained that formation of antibody to an unrelated antigen (egg albumin) may be affected.

The gamma globulin content of the sera of these animals was as high as or higher than the gamma globulin content of the sera of control animals in which antibody production was not affected.

Footnotes

¹ Present address, Leila Y. Post Montgomery Hospital, Battle Creek, Mich.