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Increased Susceptibility of Mice to Anaphylactic Shock Following Cobalt-60 Gamma Radiation¹

From the Division of Bacteriology and Virology, Medical Department, Brookhaven National Laboratory, Upton, L. I., New York and the Institute of Pathology, University of Tennessee, Memphis, Tennessee

Abstract

1. Gamma radiation exposure of 650 rep. markedly enhanced active anaphylactic shock in mice sensitized with alum-precipitated tetanus toxoid and challenged with fluid tetanus toxoid 7 days post-radiation.

2. The enhancing effect of ionizing radiation upon the severity of the anaphylactic response is not of an immediate nature, but appears during a 2- to 7-day post-radiation period.

3. Passive and reversed passive anaphylaxis was more severe in 7-day post-radiated mice sensitized with homologous antibody.

4. Irradiated mice sensitized with anti-bovine albumin rabbit serum demonstrated increased sensitivity to passive anaphylaxis when challenged 1 day later with bovine albumin antigen.

5. Seven-day post-radiated mice did not show increased sensitivity to intravenous injection of histamine.

6. The antihistaminic agents, Thephorin, Benadryl, and Pyronil, afforded almost complete protection from fatal anaphylaxis in irradiated mice.

Footnotes

¹ This research was done under the auspices of the Atomic Energy Commission.