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Studies on the Removal of the Encephalitogenic Factor from Rabies Vaccine

From the Laboratory of Biologics Control, National Microbiological Institute and the Laboratory of Pathology and Pharmacology National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Public Health Service, U. S. Department of Health, Education and Welfare, Bethesda, Md.

Abstract

By means of centrifugation at approximately 1000 G of a suspension of 5% brain tissue in distilled water, it was possible to remove a large part of the encephalitogenic factor from rabies vaccine and retain most of the mouse protective antigen in the supernatant fluid.

Footnotes

¹ Present address: Dept. of Pathology, Stritch School of Medicine, Loyola University, Chicago, Illinois.