HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Gajdusek, D. C. Articles by Yager, R. H. Search for Related Content PubMed PubMed Citation Articles by Gajdusek, D. C. Articles by Yager, R. H.

Tissue Culture Studies of Venezuelan Equine Encephalomyelitis Virus

I. Propagation in Human Uterine Tissue

From the Army Medical Service Graduate School, Walter Reed Army Medical Center, Washington, D. C.

Abstract

VEE virus, classified as a neurotropic agent, will survive and multiply in human uterine tissue fragments.

The virus has been carried through 15 subcultures in human uterine tissue and has retained its pathogenicity for mice by intracerebral inoculation. This represents a total dilution factor of the original virus of at least 10^–43.

Tissue culture flasks as here used are not as sensitive an indicator of virus infectivity as is the intracerebrally inoculated mouse.

The tissue fragments in such cultures contain considerably more virus than the supernatant fluids.