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Heterohemoantibodies in Inbred Strains of Mice

II. Immune Agglutinins and Hemolysins for Sheep and Chicken Red Cells^1,2,

From the Department of Pathology, Chicago Medical School and Mount Sinai Medical Research Foundation, Chicago, Illinois

Abstract

1. Titers of immune hemoantibodies in mice of 10 inbred strains revealed characteristic patterns for each strain, with considerable variations between strains.

2. The possible role of genetic, metabolic, and hormonal factors in relation to this difference in response of mice to immunization with hemoantigens was discussed.

3. Among 11 strains tested, all five low-tumor strains showed a high immune response, whereas of six high-tumor or high-leukemia strains, five exhibited a low immune response. A possible interpretation of these findings was presented.

Footnotes

¹ Supported (in part) by a research grant from the National Cancer Institute, (C1113) National Institutes of Health, Public Health Service.

² Presented in part at the Annual Meeting of the American Association of Immunologists on April 17, 1952.